Dr. Vlashi earned her PhD from the Department of Chemistry at Purdue University with a focus on the characterization of in vivo trafficking and dynamic accumulation of anti-cancer drugs targeted via high-affinity ligands to solid tumors. During her post-doctoral training she expanded her expertise on cancer stem cells and radiation oncology and made important discoveries that led to the development of tools for identification, tracking and targeting of cancer stem cells. Employing the unique tools for cancer stem cell identification and isolation she made the discovery that cancer stem cells reside in a metabolic state distinct from the rest of the bulk tumor cell population.
Currently, the Vlashi Lab is building on the prior seminal discoveries on cancer stem cell metabolism and is interested in investigating metabolic changes induced by radiation therapy, how these changes dictate response to therapy, and how such changes can be exploited with the goal of further enhancing benefit from radiation therapy for cancer patients. Our ultimate goal is to develop novel agents against breast cancer and glioblastoma, and their response to radiotherapy and chemotherapy are prime targets for novel anticancer therapies. In collaboration with other labs in the department Dr. Vlashi’s lab is also interested in investigating radiation mitigators for the purpose of limiting radiation toxicity to normal tissue during radiation therapy, with the ultimate goal of maximizing the therapeutic index of this powerful anti-cancer treatment modality.
We have an open post-doctoral position and invite applications from outstanding candidates with a keen interest in studying the role of tumor metabolism in promoting therapy resistance, with a focus on radiation therapy. The project involves investigation of radiation-induced reprogramming of tumor metabolism with a focus on pancreatic cancer. The overall goal will be identification of molecular players that can be targeted for therapeutic benefit.
We are seeking a motivated and technically candidate with a strong background in mammalian tissue culture, molecular biology techniques, flow cytometry and some experience with mouse tumor models. Experience in data management and bioinformatics/computational data analysis is desired but not required. Effective communication skills, a strong work ethic, ability to work both independently and in a collaborative group environment are required. Candidates must hold a doctoral degree.
Applications from women, minorities and persons with disabilities are strongly encouraged. Applicants should send curriculum vitae and 3 letters of reference to be sent (via email only) to: firstname.lastname@example.org. Applications will be continuously reviewed until the position is filled.